Securing Jugular Central Venous Catheters With Dressings Fixed to a Liquid Adhesive to Prevent Dressing Failure in Intensive Care Patients (the STICKY Trial): A Randomized Controlled Trial

Marsh, N; O'Brien, C; Larsen, EN; Alexandrou, E; Ware, RS; Pearse, I; Coyer, F; Patel, MS; Royle, RH; Rickard, CM; Sosnowski, K; Harris, PNA; Laupland, KB; Bauer, MJ; Fraser, JF; McManus, C; Byrnes, J; Corley, A

doi:10.1097/ccm.0000000000006533

Safety, quality & education

Securing Jugular Central Venous Catheters With Dressings Fixed to a Liquid Adhesive to Prevent Dressing Failure in Intensive Care Patients (the STICKY Trial): A Randomized Controlled Trial

Crit Care MedPublished 21 Feb 2025Randomised controlled trial

Primary resultResultOdds ratio 0.39 95% CI 0.20–0.76

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Authors' conclusion

MLA is associated with significantly decreased jugular CVC dressing failure and longer dressing dwell, with an acceptable safety profile.

Study context

Population: Adult ICU patients within 12 hours of jugular CVC insertion, expected to need the CVC ≥72 hours and remain in ICU ≥24 hours; 4 metropolitan Australian ICUsenrolled
Participants: 160 patients

Comparison: Intervention vs Control
Interventionn = 78
Controln = 82reference
Primary endpoint: Dressing failure due to lifting edges
Follow-up: Within 7 days

Methodological detailsmultisite, parallel group, superiority, stratified by hospital and gender

Multisite
Parallel group
Superiority
Stratified by hospital and gender

Primary result

As reported in the abstract

Odds ratio

0.39

95% CI 0.20–0.76

P = 0.005

Events by treatment group

Intervention28%22 of 78

Control50%41 of 82

Intervention vs Control

OR 0.39 (95% CI 0.20–0.76); P = 0.005

Secondary outcomes

Outcome	← Lower risk with intervention ←→ Higher risk with intervention →	IRR (95% CI)
Total number of dressing changes	0.20.5125	0.74 (0.55–0.99)
All-cause CVC failure	0.20.5125	1.44 (0.36–5.79)
	0.20.5125Incidence rate ratio (log scale)

Outcome	P value
Time to dressing failure	P = 0.12

Time to dressing failure

Did not differ between groups

All-cause CVC failure

Did not differ between groups

Safety

Events

Outcome	Intervention	Control
Skin injury	1	2

Skin injury — Three skin injuries in total: blister (intervention); maceration and skin tear (control): 3

Original publication

Securing Jugular Central Venous Catheters With Dressings Fixed to a Liquid Adhesive to Prevent Dressing Failure in Intensive Care Patients (the STICKY Trial): A Randomized Controlled Trial. Crit Care Med. Published 21 February 2025. doi:10.1097/ccm.0000000000006533

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