Selective decontamination regimens in French intensive care units (ICUs): association with reduced infection and resistance emergence
Main finding · ICU-acquired infection incidenceResult — go to the resultIncidence rate ratio 0.66 CI 0.60–0.73Authors' conclusion
These results showed that a strategy of SD was associated with reduced ICU-acquired infection incidence and decreased emergence of MDRO, while the mortality was not affected.
Study context
- Population
- Patients receiving invasive mechanical ventilation for > 24 h in French ICUs of the REA-REZO surveillance network (193 ICUs)matched cohort
- Participants
- 81,661 patients
- Exposure
- SD vs standard of care (SOC)
- SDn = 2,727
- SOCn = 2,727reference
- Outcome
- Rate of ICU-acquired infection
Methodological detailspropensity-score matched, multicentre surveillance cohort
- Propensity-score matched
- Multicentre surveillance cohort
Main finding
ICU-acquired infection incidence
Incidence rate ratio
0.66
CI 0.60–0.73
P < 0.001
SD vs SOC
IRR 0.66 (CI 0.60–0.73); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Acquisition of MDRO colonization during ICU stay
P < 0.001
ICU mortality
P = 0.689
Original publication
Selective decontamination regimens in French ICUs: association with reduced infection and resistance emergence. Ann Intensive Care. Published 25 March 2025. doi:10.
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