ICU-acquired infection in neutropenic patients
Main finding · ICU-AI incidence rateResult — go to the resultIncidence rate ratio 1.15 CI 1.05–1.25Authors' conclusion
Neutropenic patients had higher ICU-AI incidence as compared with non-neutropenic patients, specifically through an increase of BSI incidence.
Study context
- Population
- Patients admitted >48 h to 265 French intensive care units (ICUs) (REA-REZO surveillance cohort), 2018–20237,545 matched pairs
- Exposure
- Neutropenic vs non-neutropenic patients
- Outcome
- Rate of ICU-acquired infection (ICU-AI)
Methodological detailsnationwide, multicentre surveillance cohort, matched analysis
- Nationwide
- Multicentre surveillance cohort
- Matched analysis
Main finding
ICU-AI incidence rate
Incidence rate ratio
1.15
CI 1.05–1.25
P = 0.002
By group
Neutropenic vs Non-neutropenic
IRR 1.15 (CI 1.05–1.25); P = 0.002
As reported in the abstract
Observational data: associations, not effects.
Further findings
Enterobacterales among ICU-AI
P < 0.001
Coagulase negative Staphylococcus among ICU-AI
P < 0.001
Enterococcus spp. among ICU-AI
P = 0.015
| Outcome | P value |
|---|---|
| Bloodstream infection (BSI) incidence rateHigher in neutropenic · matched analysis | P < 0.001 |
| Pneumonia incidence rateComparable | P = 0.503 |
| Central-line associated BSI incidence rateComparable | P = 0.100 |
- Candida spp. among ICU-AI — Candida spp., neutropenic vs non-neutropenic · higher in neutropenic
- 10.4% vs 6.2% · P = 0.001
ICU-AI involving multidrug resistant micro-organisms
- Rates did not differ between groups
ICU-AI involving non fermenting Gram-negative bacilli
- Rates did not differ between groups
Original publication
ICU-acquired infection in neutropenic patients. Crit Care. Published 17 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →