ICU sedation, delirium & recovery
Self-reported symptoms in ICU patients and their impact on long-term outcomes—a prospective multicenter study
Authors' conclusion
A subgroup of patients with high symptom burden during ICU stay had worse physical, cognitive and mental health outcomes three months after ICU admission compared to patients with medium/low symptom burden.
Study context
- Population
- ICU patients reporting symptoms while in the ICU
- Participants
- 175 patients
- Exposure
- High vs Low/Middle ICU symptom subgroup
- Outcome
- PICS outcomes (physical disability, cognitive failure, anxiety, depression, post-traumatic stress) by validated questionnaires, dichotomized
- Follow-up
- 3 months after ICU admission
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
PICS domains
High vs Low/MiddleOdds ratio (95% CI)
Physical disability
3.31(1.25–8.78)
Cognitive failure
3.56(1.20–10.60)
Anxiety
3.70(1.41–9.67)
Depression
4.74(1.79–12.58)
Post-traumatic stress
4.38(1.49–12.84)
Observational data: associations, not effects.
Further findings
Prevalence of PICS outcomes, all patients · 3 months after ICU admission
- Physical disability
- 23.5%
- Cognitive failure
- 12.1%
- Anxiety
- 18.3%
- Depression
- 16.6%
- Post-traumatic stress
- 16.7%
Original publication
Self-reported symptoms in ICU patients and their impact on long-term outcomes—a prospective multicenter study. Intensive Care Med. Published 30 June 2025. doi:10.
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