Sepsis-associated liver dysfunction confounds the association between circulating PCSK9 concentration and mortality in septic patients: A single-center retrospective cohort study
Authors' conclusion
The association between low plasma PCSK9 concentration and mortality in sepsis may be influenced by SALD.
Study context
- Population
- Patients meeting the Sepsis-3 criteria; plasma sampled within 24 h of admission
- Participants
- 415 patients
- Exposure
- Plasma PCSK9 concentration tertiles
- Outcome
- Mortality
- Follow-up
- 28 days
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
28-day mortality
- Low PCSK9 group had higher 28-day mortality
Observational data: associations, not effects.
Further findings
PCSK9–mortality association by liver SOFA (subgroup)
- Liver SOFA ≥ 1: inverse linear correlation of PCSK9 concentration with mortality
- Liver SOFA = 0: U-shaped pattern
Adjusted PCSK9–mortality association, entire cohort
- Adjustment for international normalized ratio and liver SOFA diminished the significance of the association
Original publication
Sepsis-associated liver dysfunction confounds the association between circulating PCSK9 concentration and mortality in septic patients: A single-center retrospective cohort study. J Crit Care. Published 21 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →