Sepsis on dementia risk: A population-based cohort study with dose-dependent analysis
Main finding · All-cause dementiaResult — go to the resultHazard ratio 1.59 95 % CI 1.47–1.72Authors' conclusion
Our findings provide robust evidence of a dose-dependent association between sepsis and increased dementia risk, particularly vascular dementia, even after adjusting for competing mortality risks.
Study context
- Population
- Adults (≥18 years) without prior dementia, Taiwan's National Health Insurance Research Database (2005–2022)
- Exposure
- Sepsis vs no sepsis
- Outcome
- All-cause dementia
- Follow-up
- Up to 64 months
Methodological detailspopulation-based, propensity-score matched, landmark analysis, competing-risk analysis
- Population-based
- Propensity-score matched
- Landmark analysis
- Competing-risk analysis
Main finding
As reported in the abstract
Hazard ratio
1.59
95 % CI 1.47–1.72
P < 0.0001
Sepsis vs Non-sepsis
HR 1.59 (95 % CI 1.47–1.72); P < 0.0001
Observational data: associations, not effects.
Further findings
All-cause dementia, multiple sepsis episodes (dose-response)
| sHR (95 % CI) | ||
|---|---|---|
| Multiple sepsis episodesHighest dementia risk · Fine-Gray model, competing risk of death | 1.63 (1.39–1.91) | |
| 0.512Subdistribution hazard ratio (log scale) |
Vascular dementia · strongest association
P = 0.0003
Original publication
Sepsis on dementia risk: A population-based cohort study with dose-dependent analysis. J Crit Care. Published 3 May 2025. doi:10.
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