Sepsis subphenotypes, theragnostics and personalized sepsis care
Authors' conclusion
This suggests that future clinical trials that take a precision medicine approach will have a higher likelihood of identifying effective therapeutics for patients based on their subphenotype.
Study context
- Population
- Critically ill patients with sepsis
Main finding
As reported in the abstract
- Machine learning plus improved understanding of sepsis biology has identified patient subphenotypes
- Re-analyses of completed trials: patients with different subphenotypes may respond differently to treatments
- Review describes emerging subphenotypes in the critically ill and promising immune modulation therapies that could benefit some subphenotypes
Original publication
Sepsis subphenotypes, theragnostics and personalized sepsis care. Intensive Care Med. Published 31 March 2025. doi:10.
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