Hemodynamics, fluids & transfusion
Serum chloride concentration and outcomes in adults receiving intravenous fluid therapy with a balanced crystalloid solution or 0.9% sodium chloride
Authors' conclusion
There were no significant differences in the treatment effect of balanced solutions compared to saline according to baseline serum chloride concentration or pH.
Study context
- Population
- Intensive Care Unit (ICU) patients receiving intravenous fluid therapyof 4846 with outcome data
- Participants
- 4,823 patients
- Comparison
- Balanced solution vs 0.9% sodium chloride
- Primary endpoint
- Mortality
- Follow-up
- Day 90
Methodological detailssubgroup analysis by quartiles of baseline serum chloride and pH
- Subgroup analysis by quartiles of baseline serum chloride and pH
Primary result
As reported in the abstract
Day-90 mortality by baseline serum chloride quartile (subgroup)
Balanced solution vs SalineRisk-adjusted OR (95% CI)
Chloride < 102 mmol/L (n = 1347)
1.23(0.95–1.58)
Chloride 102-106 mmol/L (n = 1333)
0.95(0.73–1.25)
Chloride 107-109 mmol/L (n = 993)
0.88(0.64–1.21)
Chloride > 109 mmol/L (n = 1150)
0.76(0.57–1.01)
Further findings
| Outcome | Risk-adjusted OR (95% CI) | |
|---|---|---|
| Day-90 mortality by baseline pH quartile (subgroup)Balanced solution vs Saline · pH ≤ 7.27 | 0.89 (0.69–1.15) | |
| Day-90 mortality by baseline pH quartile (subgroup)Balanced solution vs Saline · pH 7.27-7.34 | 0.94 (0.70–1.27) | |
| Day-90 mortality by baseline pH quartile (subgroup)Balanced solution vs Saline · pH 7.34-7.39 | 0.96 (0.67–1.38) | |
| Day-90 mortality by baseline pH quartile (subgroup)Balanced solution vs Saline · pH > 7.39 | 1.15 (0.82–1.60) | |
| 0.512Risk-adjusted OR (log scale) |
- Day-90 mortality by baseline pH quartile (subgroup): P value for interaction = 0.63
Original publication
Serum chloride concentration and outcomes in adults receiving intravenous fluid therapy with a balanced crystalloid solution or 0.9% sodium chloride. Intensive Care Med. Published 10 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →