Cardiothoracic & vascular anesthesia
Serum Levels of Bupivacaine After Bilateral Ultrasound-Guided Deep Parasternal Intercostal Plane Block in Cardiac Surgery with Median Sternotomy
Authors' conclusion
Bilateral PIP placed at the end of cardiac surgery resulted in low systemic bupivacaine levels. The inclusion of additives shortened Tmax without improving outcome.
Study context
- Population
- Adults undergoing cardiac surgery with median sternotomy receiving bilateral ultrasound-guided deep parasternal intercostal plane (parasternal intercostal plan (PIP)) block with 2.5 mg/kg bupivacaine with or without dexamethasone and dexmedetomidine
- Participants
- 28 adults
- Outcome
- Serum bupivacaine pharmacokinetics
Methodological detailssingle-centre, academic university hospital
- Single-centre
- Academic university hospital
Main finding
As reported in the abstract
Mean peak bupivacaine concentration (± 0.62 µg/mL)
0.60 µg/mL
Mean Tmax (± 12.97 minutes)
16.92 minutes
Concentration >2.0 µg/mL within 15 minutes of block placement, 2 patients
7.1%
Observational data: associations, not effects.
Further findings
Tmax, no additives vs additives · significantly greater without additives
P = 0.004
Time to extubation and postoperative pain, additives vs none
- Not improved with additives
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →