Hemodynamics, fluids & transfusion
Severe hypotension but not systemic inflammation or endothelial activation predicts encephalopathy in circulatory shock
Authors' conclusion
In circulatory shock, encephalopathy is most strongly associated with recurrent/severe hypotension (MAP <50 mmHg) and markers of neuroinflammation, not systemic inflammation or endothelial activation.
Study context
- Population
- Intensive care unit (ICU) patients with circulatory shock
- Participants
- 198 patients
- Exposure
- Factors associated with encephalopathy in circulatory shock
- Septic shockn = 95
- Non-septic shockn = 103
- Outcome
- Encephalopathy (coma and delirium; GCS, RASS, CAM-ICU)
Methodological detailsmultivariable logistic regression, mixed-effect models
- Multivariable logistic regression
- Mixed-effect models
Main finding
As reported in the abstract
Factors associated with encephalopathy (multivariable logistic regression)
Odds ratio (CI)P value
Severe hypotension
2.56(1.18–4.75)
P = 0.022Longer sedation duration
1.09(1.02–1.18)
P = 0.017ICU-acquired infections
1.61(0.73–3.54)
P = 0.021Elevated S100B
1.72(0.66–3.65)
P = 0.03- Encephalopathy
- 140 patients (71%)
Observational data: associations, not effects.
Further findings
Encephalopathy and structural brain injury, septic vs non-septic shock
- Prevalence similar to non-septic shock despite higher systemic inflammation in septic shock
Original publication
Severe hypotension but not systemic inflammation or endothelial activation predicts encephalopathy in circulatory shock. Ann Intensive Care. Published 18 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →