Sex difference in the risk of extubation failure in intensive care units (ICUs)
Primary result · Reintubation within 7 days after extubationResult — go to the resultDifference + 5.6% 95% CI - 0.3 to 10.8Authors' conclusion
In this post hoc analysis of a clinical trial including a homogeneous subset of patients at high risk of extubation failure, sex was independently associated with reintubation.
Study context
- Population
- ICU patients at high risk of extubation failure
- Participants
- 641 patients
- Comparison
- Males vs females
- Malesn = 425
- Femalesn = 216reference
- Primary endpoint
- Reintubation
- Follow-up
- 7 days following extubation
Methodological detailsmultivariable logistic regression
- Multivariable logistic regression
Primary result
Reintubation within 7 days after extubation · day 7
Difference
+ 5.6%
95% CI - 0.3 to 10.8
P = 0.059
By group
As reported in the abstract
- Male sex independently associated with reintubation within 7 days, multivariable logistic regression
- adjusted OR 1.70 [95% CI, 1.01 to 2.89]; P = 0.048 (95% CI, P)
Further findings
Reintubation at 48 h
difference + 5.0 (0.2–9.2) · P = 0.038
Original publication
Sex difference in the risk of extubation failure in ICUs. Ann Intensive Care. Published 19 December 2023. doi:10.
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