Cardiac arrest & resuscitation
Sex hormone trajectories and association to outcomes after out-of-hospital cardiac arrest
Authors' conclusion
Survivors and those with favorable neurological outcome had lower trend in estrone. The sex hormone estrone, present in both males and females, may be a predictor of survival. When adjusted for estrogens, female sex had better neurological recovery compared to males. The difference in neurological outcome by sex is not explained by estrogens.
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) patients who survived to hospital admissionmean age 61.3 (+15.7) years
- Participants
- 94 patients
- Exposure
- Males vs Females
- Malesn = 50reference
- Femalesn = 44
- Outcome
- Survival and neurological outcome (cerebral performance category 1-2 good, 3-5 poor) in association with sex hormone trajectories
Main finding
As reported in the abstract
β
−3.38
95% CI −5.71 to −0.85
Lower estrone level · survival at discharge; adjusted for time, sex, age, and hormones
β
1.27
95% CI 0.01–2.53
Females vs Males · better neurological scores, adjusted for estrone
β
2.92
95% CI 1.13–4.70
Females vs Males · better neurological scores, adjusted for estradiol
Observational data: associations, not effects.
Original publication
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