Respiratory failure & ventilation
Sex-Specific Differences in Tidal Volumes and Mortality of Mechanically Ventilated Patients
Main finding · Daily tidal volumes and mortalityResult — go to the resultDifference +0.6 mL/kg PBW 95% CrI +0.6 to +0.7Study context
- Population
- Adults mechanically ventilated ≥24 hours in 9 ICUs of 6 University of Toronto-affiliated hospitals, Toronto Intensive Care Observational Registry, April 2014–December 2022
- Participants
- 20,351 eligible patients
- Exposure
- Female vs male patients
- Femalen = 7,635
- Malen = 12,716reference
- Outcome
- Daily tidal volumes and mortality
Methodological detailsBayesian joint models, multicentre registry
- Bayesian joint models
- Multicentre registry
Main finding
As reported in the abstract
Difference
+0.6 mL/kg PBW
95% CrI +0.6 to +0.7
- Each 1 mL/kg predicted body weight (PBW) increase in daily tidal volume associated with higher mortality, HR (95% CrI 1.07-1.13), adjusted for time-varying severity of illness
- 1.10
Observational data: associations, not effects.
Further findings
Unadjusted mortality
Ventilation without recorded body height
| Outcome | Difference (cm H 2 O) (95% CrI) |
|---|---|
| Driving pressures | +1 (1–1) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Sex-Specific Differences in Tidal Volumes and Mortality of Mechanically Ventilated Patients. Crit Care Med. Published 31 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →