Short-course versus prolonged-course antibiotic regimens for ventilator-associated pneumonia: A systematic review and meta-analysis of randomized controlled trials
Pooled result · 28-day mortality; recurrence of pneumoniaResult — go to the resultRelative risk 1.73 95% CI 1.17–2.54Authors' conclusion
Low-quality evidence suggests that a short course of antibiotics is associated with a higher recurrence of pneumonia in NF-GNB VAP with no difference in mortality as compared to a prolonged course.
Study context
- Population
- Patients with ventilator-associated pneumonia (VAP)6 randomized controlled trials (RCTs)
- Comparison
- Short- vs prolonged-course antibiotic regimens
- Outcome
- 28-day mortality; recurrence of pneumonia
Pooled result
As reported in the abstract
Relative risk
1.73
95% CI 1.17–2.54
Short course vs Prolonged course
RR 1.73 (95% CI 1.17–2.54)
Further pooled results
Clinical resolution, ICU LOS, duration of mechanical ventilation
- No significant difference between the two regimens
Original publication
Short-course versus prolonged-course antibiotic regimens for ventilator-associated pneumonia: A systematic review and meta-analysis of randomized controlled trials. J Crit Care. Published 27 May 2023. doi:10.
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