Simplified rapid hydration and contrast-associated acute kidney injury among CKD patients stratified by Mehran score: sub-analysis from the TIME Trial
Authors' conclusion
The preventive effect of SH in CA-AKI was similar to standard hydration regardless of MRS-guided risk stratification.
Study context
- Population
- CKD patients undergoing coronary angiography, stratified by Mehran risk score (low to moderate-risk; high to very high-risk)
- Participants
- 954 patients
- Comparison
- Simplified rapid hydration vs standard hydration
- Primary endpoint
- Incidence of contrast-associated AKI (CA-AKI) and acute heart failure (AHF)
Methodological detailssubgroup analysis by Mehran risk score
- Subgroup analysis by Mehran risk score
Primary result
As reported in the abstract
CA-AKI
- SH vs Standard hydration: P = 0.5342
- SH vs Standard hydration: P = 0.6392
Secondary outcomes
Association of Mehran risk score with contrast-associated acute kidney injury (CA-AKI)
| OR (95% CI) | P value | ||
|---|---|---|---|
| MRS | 1.101 (1.049–1.156) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Renal function indexes and inflammatory indicators · 24 h, 48 h, and 72 h after PCI
- Possible subtle differences between SH and control at different time points
Original publication
Simplified rapid hydration and contrast-associated acute kidney injury among CKD patients stratified by Mehran score: sub-analysis from the TIME Trial. Perioper Med (Lond). Published 14 October 2024. doi:10.
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