Regional anesthesia

Single-shot perineural femoral nerve block and falls after lower limb orthopaedic surgery: a systematic review and meta-analysis

Br J AnaesthPublished Systematic review and meta-analysis of randomised trials

Pooled result · FallsResult — go to the resultRelative risk 3.62 95% CI 1.83–7.19

Authors' conclusion

Compared with techniques that avoid femoral nerve inhibition, there is moderate-quality evidence that sFNB increases fall risk and very-low-quality evidence that sFNB increases buckling and near-fall risk in the early convalescent phase.

Study context

Population
Patients undergoing lower limb orthopaedic surgery31 trials
Comparison
Single-shot femoral nerve block vs no sFNB
Outcome
Falls (early postoperative)
Methodological detailsGRADE evidence certainty, prospectively registered
  • GRADE evidence certainty
  • Prospectively registered

Pooled result

Falls

Relative risk

3.62

95% CI 1.83–7.19

P = 0.0002

sFNB vs Non-recipients
RR 3.62 (95% CI 1.83–7.19); P = 0.0002

As reported in the abstract

Further pooled results

OutcomeRRP value
Falls: sFNB vs all non-motor block techniques combined (adductor canal/iliopsoas plane block and local anaesthetic infiltration)2.75P = 0.02
Falls: sFNB vs neuraxial blockade6.35P = 0.03
Falls: sFNB vs systemic analgesia6.43P = 0.03
BucklingFive studies · very-low-quality evidence5.95
Near-fallsFour studies · very-low-quality evidence4.56

Original publication

Single-shot perineural femoral nerve block and falls after lower limb orthopaedic surgery: a systematic review and meta-analysis. Br J Anaesth. Published 1 January 2026. doi:10.1016/j.bja.2025.11.018

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