Skin biopsy in adult patients with meningococcal purpura fulminans: a multicenter retrospective cohort study
Authors' conclusion
Skin biopsy with conventional culture and meningococcal PCR has a global sensitivity of 88%
Study context
- Population
- Adults admitted to the ICU for meningococcal purpura fulminans with skin biopsy (conventional and/or meningococcal polymerase chain reaction (PCR))68 with skin biopsy
- Participants
- 61 vs 51
- Exposure
- Standard culture vs PCR
- Standard culturen = 61
- PCRn = 51
- Outcome
- Sensitivity of skin biopsy (contributive skin biopsy)
Methodological detailsmulticentre, 17-year, Skin biopsy performed median 1 day after antibiotic initiation
- Multicentre
- 17-year
- Skin biopsy performed median 1 day after antibiotic initiation
Main finding
As reported in the abstract
Skin biopsy contributive (global sensitivity)
- Skin biopsy contributive overall
- 60/68 (88%)
Observational data: associations, not effects.
Further findings
Meningococcal serogroup identified with skin biopsy
- Serogroup identified
- 48/68 (71%)
Positive PCR performed ≥3 days after antibiotic initiation
- Positive PCRs performed 3 days or more after antibiotic initiation
- 5
- Of 50 positive PCRs
Original publication
Skin biopsy in adult patients with meningococcal purpura fulminans: a multicenter retrospective cohort study. Crit Care. Published 30 April 2023. doi:10.
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