Perioperative medicine & outcomes
Sleep Apnea-Specific Hypoxic Burden and Postoperative Outcomes of Major Noncardiothoracic Surgery
Authors' conclusion
Among OSA patients undergoing major noncardiothoracic surgery, SASHB was significantly associated with the risk of 30-day postoperative mortality and CV complications.
Study context
- Population
- Adults diagnosed with obstructive sleep apnea (OSA) (May 2007–December 2018) who underwent major noncardiothoracic surgery between diagnosis and December 2024
- Participants
- 2,286 adults
- Exposure
- Higher vs low sleep apnea-specific hypoxic burden at OSA diagnosis
- Outcome
- Composite of:
- Stroke
- AF
- HF
- MI
- VTE
- All-cause mortality
- Follow-up
- 30 days of surgery
Methodological detailslinked with health administrative database
- Linked with health administrative database
Main finding
As reported in the abstract
30 days
Each group vs low SASHBAdjusted odds ratio (95% CI)
SASHB 32 to <80%
1.76(0.86–3.59)
High SASHB
2.79(1.42–5.49)
- Primary outcome overall
- 80 patients (3.5%)
Observational data: associations, not effects.
Further findings
Risk score (age, emergency admission before surgery, sleep apnea-specific hypoxic burden (SASHB)) for primary outcome
- AUC
- 0.73; 95% CI, 0.68-0.77
Simplified SASHB derived from single oximetry signal
- Similar findings
Original publication
Sleep Apnea-Specific Hypoxic Burden and Postoperative Outcomes of Major Noncardiothoracic Surgery. JAMA Netw Open. Published 2 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →