Respiratory failure & ventilation
Smoking on the risk of acute respiratory distress syndrome: a systematic review and meta-analysis
Pooled result · ARDS riskResult — go to the resultOdds ratio 1.67 95% CI 1.33–2.08Authors' conclusion
There is a strong association between smoking and elevated ARDS risk.
Study context
- Population
- Adults with clinical risk factors for acute respiratory distress syndrome (ARDS)
- Participants
- 36,995 adults · 26 observational studies
- Comparison
- Smoking vs no smoking
- Outcome
- ARDS risk
Methodological detailsDatabases searched January 1, 2000, to December 31, 2023
- Databases searched January 1, 2000, to December 31, 2023
Pooled result
As reported in the abstract
Odds ratio
1.67
95% CI 1.33–2.08
P < 0.001
Smoking vs Control
OR 1.67 (95% CI 1.33–2.08); P < 0.001
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| ARDS risk, patient-reported smoking history (subgroup) | 1.78 (1.38–2.28) | P < 0.001 | |
| ARDS with extrapulmonary etiologies (subgroup) | 1.85 (1.43–2.38) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
| Outcome | MD (95% CI) | P value |
|---|---|---|
| AgeSmoking group younger | - 7.15 (- 11.58 to - 2.72) | P = 0.002 |
ARDS risk, smoking identified by tobacco metabolites (cotinine, NNAL) (subgroup)
- No significant difference in ARDS risk in patients identified by tobacco metabolite detection
- OR 1.19; 95% CI 0.69-2.05; P = 0.53
Original publication
Smoking on the risk of acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care. Published 14 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →