SOFA-2 score predicts mortality in pneumonia-associated sepsis: a retrospective cohort study
Authors' conclusion
In patients with pneumonia-associated sepsis, the SOFA-2 score exhibited a predictive performance for 28-day mortality risk similar to that of the conventional SOFA score. Although its standalone use did not show superiority, integrating SOFA-2 with key clinical variables into a composite model significantly enhanced predictive accuracy.
Study context
- Population
- Adults meeting Sepsis-3 criteria with pneumonia as the infection source (MIMIC-IV; external validation Intensive Care Unit (ICU) cohort, Shandong Provincial Hospital)MIMIC-IV n = 7,150
- Exposure
- SOFA-2 vs Sequential Organ Failure Assessment (SOFA) score for predicting 28-day mortality
- Outcome
- 28-day all-cause mortality
- Follow-up
- 28 days
Methodological detailsexternal validation
- External validation
Main finding
As reported in the abstract
| Group | AUC day 1 | AUC day 28 |
|---|---|---|
| SOFA-2 | 0.78 | 0.61 |
| SOFA | 0.79 | 0.62 |
AUC day 1
AUC day 28
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| 28-day survival by SOFA-2 cutoff 11 (MaxStat) · 28 daysHigh score (> 11) vs Low score · significantly lower 28-day survival in high-score group | P < 0.001 |
28-day all-cause mortality, MIMIC-IV cohort
- 28-day all-cause mortality
- 28.1%
SOFA-2 as independent predictor of 28-day mortality (multivariable analysis)
- SOFA-2 an independent predictor of 28-day mortality
Composite SOFA-2 model predictive performance · day 1
- Composite SOFA-2 model significantly improved predictive performance; day-1 AUC
- 0.87
SOFA-2 and prognosis across subgroups (subgroup)
- Association consistent across characteristic subgroups
External validation
- Confirmed independent prognostic value and risk-stratification ability of SOFA-2
Original publication
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