Cardiothoracic & vascular anesthesia
Soluble DLL1 as an Indicator of acute kidney injury and postoperative delirium following cardiac surgery: a secondary analysis of a prospective study
Authors' conclusion
This study demonstrates that sDLL1 provides moderate predictive value for AKI and POD after cardiac surgery and may provide valuable insights into postoperative complications.
Study context
- Population
- Elective cardiac surgery patients
- Participants
- 90 patients
- Comparison
- Acute kidney injury (AKI) vs no AKI; Postoperative delirium (POD) vs no POD
- Primary endpoint
- sDLL1 levels and their relationship with and predictive value for AKI and POD
Primary result
As reported in the abstract
Postoperative plasma sDLL1 by AKI status · postoperatively
| Group | Value | AKI incidence | AUC | Sensitivity | Specificity |
|---|---|---|---|---|---|
| No AKI | 6308.49 (range 5121.27–7955.28) ng/mL | ||||
| AKI | 7,714.77 (range 7151.06–10,514.73) ng/mL | 6.1% | 0.63 | 0.91 | 0.53 |
Value
No AKI6308.49 (range 5121.27–7955.28) ng/mL
AKI7,714.77 (range 7151.06–10,514.73) ng/mL
AKI incidence
No AKI— not stated in the abstract
AKI6.1%
AUC
No AKI— not stated in the abstract
AKI0.63
Sensitivity
No AKI— not stated in the abstract
AKI0.91
Specificity
No AKI— not stated in the abstract
AKI0.53
- AKI vs no AKI: P = 0.01 — significantly elevated in AKI
Further findings
Postoperative sDLL1 and POD · postoperatively
- POD incidence
- 23.3%
- AUC for POD
- 0.72
- Sensitivity for POD
- 0.64
- Specificity for POD
- 0.73
- Postoperative sDLL1 significantly elevated in patients with POD
Original publication
Soluble DLL1 as an Indicator of acute kidney injury and postoperative delirium following cardiac surgery: a secondary analysis of a prospective study. Perioper Med (Lond). Published 7 August 2025. doi:10.
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