Soluble triggering receptor expressed on myeloid cells-1 as a predictive biomarker in sepsis: insights into cut-offs, mortality risk, and treatment guidance—secondary analysis of the Next GeneSiS-Trial
Authors' conclusion
Elevated sTREM-1 concentrations particularly occur in patients with a high degree of organ damage, who are at high risk for adverse outcomes.
Study context
- Population
- Patients with sepsis or septic shockanalysed
- Participants
- 500 patients
- Comparison
- sTREM-1 levels by sepsis severity, outcome and clinical factors
Methodological detailsnon-interventional, multicentre
- Non-interventional
- Multicentre
Primary result
As reported in the abstract
Median sTREM-1
P < 0.001
Further findings
sTREM-1 by outcome and organ support
- Higher sTREM-1 in non-survivors and in those needing RRT, mechanical ventilation or with positive Sepsis-Induced-Coagulopathy (SIC) score
- P < 0.001
sTREM-1 by quartiles of clinical variables
- Higher in highest quartile of fluid balance and SOFA; lower in highest quartile of Horowitz Index and platelet count
sTREM-1 by site of infection or blood culture
- Slight significant differences on day one, no longer detectable by day three
Best sTREM-1 cut-off for survival vs non-survival · day 28
- Cut-off (CI 297-505) pg/ml
- 408
Original publication
Soluble triggering receptor expressed on myeloid cells-1 as a predictive biomarker in sepsis: insights into cut-offs, mortality risk, and treatment guidance—secondary analysis of the Next GeneSiS-Trial. Crit Care. Published 21 April 2026. doi:10.
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