Hemodynamics, fluids & transfusion
Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care: The STRATUS Randomized Clinical Trial
Authors' conclusion
Use of small-volume blood collection tubes in the ICU may decrease RBC transfusions without affecting laboratory analysis.
Study context
- Population
- Patients in 25 adult medical-surgical Intensive Care Unit (ICUs) in Canada, 2019–2021primary analysis, ICU stay ≥48 h
- Participants
- 21,201 patients
- Comparison
- Small-volume vs standard-volume blood collection tubes
- Small-volumen = 10,261
- Standard-volumen = 10,940reference
- Primary endpoint
- RBC transfusion (units per patient per ICU stay)
Methodological detailscluster randomized, multicentre, Trial hiatus of 5.5 months related to COVID-19
- Cluster randomized
- Multicentre
- Trial hiatus of 5.5 months related to COVID-19
Primary result
As reported in the abstract
RBC transfusion (units per patient per ICU stay), small-volume vs standard-volume tubes
RR for red blood cell (RBC) units per patient per ICU stay (95% CI, 0.79 to 1.05; P = .19), no significant difference
0.91
Absolute reduction in RBC units/100 patients per ICU stay
7.24
95% CI −3.28 to 19.44
Secondary outcomes
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| RBC units per patient per ICU stay, prespecified secondary analysis (n = 27 411) | 0.88 (0.77–1.00) | P = 0.04 | |
| 0.512Relative risk (log scale) |
- RBC units per patient per ICU stay, prespecified secondary analysis (n = 27 411): absolute reduction of 9.84 RBC units/100 patients per ICU stay (95% CI, 0.24 to 20.76)
Decrease in transfusion-adjusted Hb, primary population
- Mean difference in g/dL (95% CI, −0.04 to 0.23), not statistically different
- 0.10
Decrease in transfusion-adjusted Hb, secondary population
- Mean difference in g/dL (95% CI, 0.05 to 0.29), lower
- 0.17
Specimens with insufficient quantity for analysis
- Rare before and after transition
- ≤0.03%
Original publication
Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care: The STRATUS Randomized Clinical Trial. JAMA. Published 21 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →