Respiratory failure & ventilation
Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation
Primary result · Clinically important upper GI bleeding in the ICUResult — go to the resultHazard ratio 0.30 95% CI 0.19–0.47Authors' conclusion
Among patients undergoing invasive ventilation, pantoprazole resulted in a significantly lower risk of clinically important upper gastrointestinal bleeding than placebo, with no significant effect on mortality.
Study context
- Population
- Critically ill adults undergoing invasive ventilation
- Participants
- 4,821 adults · 68 intensive care unit (ICUs)
- Comparison
- IV pantoprazole 40 mg daily vs placebo
- Primary endpoint
- Clinically important upper GI bleeding in the ICU (primary efficacy outcome); primary safety outcome death from any cause at 90 days
- Follow-up
- 90 days
Methodological detailsinternational, placebo-controlled
- International
- Placebo-controlled
Primary result
As reported in the abstract
Clinically important upper GI bleeding in the ICU
Hazard ratio
0.30
95% CI 0.19–0.47
P < 0.001
Events by treatment group
Pantoprazole vs Placebo
HR 0.30 (95% CI 0.19–0.47); P < 0.001
Secondary outcomes
| Outcome | Pantoprazole | Placebo | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Death from any cause (primary safety outcome) · 90 daysDenominators 2390 vs 2379 | 29.1% | 30.9% | 0.94 (0.85–1.04) | P = 0.25 | |
| 0.512Hazard ratio (log scale) |
Patient-important bleeding
- Reduced with pantoprazole
Other secondary outcomes (incl. VAP, Clostridioides difficile infection)
- Similar in the two groups
- Multiplicity-adjusted
Original publication
Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation. N Engl J Med. Published 14 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →