Study on the diagnostic role of exosome-derived miRNAs in postoperative septic shock and non-septic shock patients
Authors' conclusion
This study highlights extracellular vesicle-derived miRNAs as promising biomarkers for differentiating septic from non-septic shock.
Study context
- Population
- Postsurgical shock patients in ICUs of two Spanish hospitals
- Participants
- 109 vs 52
- Comparison
- Discovery vs Validation
- Discoveryn = 109
- Validationn = 52
- Outcome
- Diagnostic performance of extracellular vesicle-derived miRNAs to differentiate septic from non-septic shock
Methodological detailsmulticentre, prospective, discovery and validation cohorts
- Multicentre
- Prospective
- Discovery and validation cohorts
Performance
As reported in the abstract
Three-miRNA combination (miR-100-5p, miR-148a-3p, miR-451a) for septic shock
| Test or model | AUC |
|---|---|
| Discovery | 0.894 |
| Validation | 0.960 |
AUC
Discovery0.894
Validation0.960
- Six miRNAs (miR-100-5p, miR-484, miR-10a-5p, miR-148a-3p, miR-342-3p, miR-451a) with strong diagnostic capabilities
- 6
Original publication
Study on the diagnostic role of exosome-derived miRNAs in postoperative septic shock and non-septic shock patients. Crit Care. Published 3 March 2025. doi:10.
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