Subanaesthetic doses of ketamine reduce but do not eliminate predictive coding responses: implications for mechanisms of sensory disconnection
Authors' conclusion
Subanaesthetic dosing of ketamine reduced correlates of predictive coding but did not eliminate them.
Study context
- Population
- Participants receiving ketamine up to a blood concentration of 0.3 μg ml-1 while hearing a roving oddball tone sequence
- Participants
- 14 participants
- Comparison
- Subanaesthetic ketamine vs before ketamine
- Outcome
- EEG correlates of prediction errors (predictive coding)
Methodological detailsdose-escalation, EEG evoked response potentials, Bayesian observer model
- Dose-escalation
- EEG evoked response potentials
- Bayesian observer model
Main finding
As reported in the abstract
- Transitional probability prediction error reduced at ketamine 0.2-0.3 μg ml-1 (96-208 ms)
- P=0.003
- Correlates of prediction error still evident in the EEG (124-168 ms)
- P=0.003
- Environmental volatility prediction errors associated with EEG activity before ketamine (224-284 ms)
- P=0.028
- Environmental volatility prediction errors associated with EEG activity during 0.2-0.3 μg ml-1 ketamine (108-248 ms)
- P=0.003
Original publication
Subanaesthetic doses of ketamine reduce but do not eliminate predictive coding responses: implications for mechanisms of sensory disconnection. Br J Anaesth. Published 3 August 2023. doi:10.
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