Perioperative medicine & outcomes
Subcutaneous glucose tracking during extreme perioperative perfusion stress: a prospective microdialysis study
Authors' conclusion
Under recovery-corrected and one-point-calibrated conditions, subcutaneous glucose retained interpretable tracking of arterial glucose during extreme perioperative perfusion stress.
Study context
- Population
- Adults undergoing pulmonary endarterectomy with deep hypothermic circulatory arrest743 paired measurements
- Participants
- 20 adults
- Exposure
- Calibrated subcutaneous glucose vs arterial glucose; upper thoracic vs periumbilical site
- Outcome
- Agreement of calibrated subcutaneous glucose with arterial glucose (ARD)
Methodological detailsmicrodialysis, repeated-measures Bland-Altman analysis, exploratory mixed-effects models
- Microdialysis
- Repeated-measures Bland-Altman analysis
- Exploratory mixed-effects models
Main finding
As reported in the abstract
ARD vs arterial glucose, overall
Overall median absolute relative difference (ARD) (IQR 5.9-21.9)
12.9%
Overall mean ARD (SD 17.2)
17.2%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| ARD by anatomical sitePhase-adjusted analysis | P = 0.053 |
- ARD by anatomical site: numerically more favourable at upper thoracic site; not significant in phase-adjusted analysis
ARD by procedural phase
- Phase associated with ARD; greatest discordance during rewarming and early postoperative recovery rather than DHCA interval
- global P < 0.001
- Exploratory mixed-effects models
Original publication
Subcutaneous glucose tracking during extreme perioperative perfusion stress: a prospective microdialysis study. J Clin Monit Comput. Published 19 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →