Perioperative Fully Closed-loop Versus Usual Care Glucose Management in Adults Undergoing Major Abdominal Surgery: A Two-centre Randomized Controlled Trial
Authors' conclusion
The FCL approach resulted in significantly better glycemic control compared with UC management, without increasing the risk of hypoglycemia.
Study context
- Population
- Adults undergoing major abdominal surgery anticipated to experience prolonged stress hyperglycemiaincluded in the analysis
- Participants
- 37 adults
- Comparison
- Fully closed-loop (FCL) vs usual care (UC)
- FCLn = 18
- UCn = 19reference
- Primary endpoint
- Proportion of time with sensor glucose in target range 5.6 to 10.0 mmol/L
Methodological detailstwo-centre
- Two-centre
Primary result
As reported in the abstract
P < 0.001
Further findings
Mean glucose
P = 0.015
Safety
Time in hypoglycemia (<3.0 mmol/L)
- Low in either group
Study-related serious adverse events
- No study-related serious adverse events occurred
Original publication
Perioperative Fully Closed-loop Versus Usual Care Glucose Management in Adults Undergoing Major Abdominal Surgery: A Two-centre Randomized Controlled Trial. Ann Surg. Published 30 September 2024. doi:10.
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