Subjective experiences during dexmedetomidine- or propofol-induced unresponsiveness and non-rapid eye movement sleep in healthy male subjects
Authors' conclusion
Anaesthetic-induced unresponsiveness and NREM sleep are characterised by disconnected conscious experiences with corresponding recall frequencies and content.
Study context
- Population
- Healthy males
- Participants
- 20 / 19 / 37
- Comparison
- Anaesthetic-induced unresponsiveness vs non-rapid eye movement (NREM) sleep
- Dexmedetomidinen = 20
- Propofoln = 19
- NREM sleepn = 37reference
- Outcome
- Prevalence and content of experiences in reports after anaesthetic-induced unresponsiveness and NREM sleep
Methodological detailswithin-subject design
- Within-subject design
Main finding
As reported in the abstract
Interviews including experiences
| Group | Value | Interviews |
|---|---|---|
| Anaesthesia | 69.7% | 76 |
| NREM sleep | 64.4% | 73 |
Value
Anaesthesia69.7%
NREM sleep64.4%
Interviews
Anaesthesia76
NREM sleep73
- Anaesthesia vs NREM sleep: P = 0.581 — recall did not differ
- Recall did not differ between dexmedetomidine and propofol in any of the three awakening rounds
- P > 0.05
Further findings
| Outcome | NREM sleep | P value |
|---|---|---|
| Disconnected dream-like experiencesAnaesthesia vs NREM sleep | 51.1% | P = 0.418 |
| Memory incorporation of the research settingAnaesthesia vs NREM sleep | 78.7% | P = 0.204 |
| RousabilityDexmedetomidine vs Propofol · most rousable, no difference | P = 0.480 |
- Rousability — Lower plasma concentrations associated with being rousable, dexmedetomidine
- P=0.007
- Rousability — Lower plasma concentrations associated with being rousable, propofol
- P=0.002
- Rousability — Plasma concentration not associated with recall, dexmedetomidine
- P=0.543
- Rousability — Plasma concentration not associated with recall, propofol
- P=0.460
- Disconnected dream-like experiences: Anaesthesia 62.3%
- Memory incorporation of the research setting: Anaesthesia 88.7%
Awareness (connected consciousness)
- Rarely reported in either state
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Subjective experiences during dexmedetomidine- or propofol-induced unresponsiveness and non-rapid eye movement sleep in healthy male subjects. Br J Anaesth. Published 31 May 2023. doi:10.
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