Surgical Antibiotic Prophylaxis Dosing in Adult Patients with Obesity: A Comprehensive Review of Pharmacokinetic and Pharmacodynamic Data
Authors' conclusion
Except for metronidazole, cefoxitin, and gentamicin, there is currently no evidence suggesting the need for dosing adjustments.
Study context
- Population
- Adult surgical patients with obesity receiving antibiotic prophylaxis30 studies
- Comparison
- Obesity-related dosing adjustments in surgical antibiotic prophylaxis
- Outcome
- Pharmacokinetic parameters (plasma and interstitial fluid concentrations, AUC in plasma and interstitial fluid, other pharmacokinetic measures)
Methodological detailsMEDLINE and Cochrane Library searched
- MEDLINE and Cochrane Library searched
Main finding
As reported in the abstract
Need for obesity-related dosing adjustment
- No current evidence of need for dosing adjustments, except for metronidazole, cefoxitin and gentamicin
- Antibiotics studied: cefazolin, cefoxitin, cefuroxime, piperacillin/tazobactam, meropenem, ertapenem, metronidazole, vancomycin, ciprofloxacin, gentamicin
Original publication
Surgical Antibiotic Prophylaxis Dosing in Adult Patients with Obesity: A Comprehensive Review of Pharmacokinetic and Pharmacodynamic Data. Anesthesiology. Published 8 April 2025. doi:10.
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