Surgical Antimicrobial Prophylaxis in Low-risk Cholecystectomies is Associated With Fewer Surgical Site Infections: Nationwide Cohort Study in Switzerland
Main finding · SSIResult — go to the resultAdjusted odds ratio 0.50 95% CI 0.35–0.70Authors' conclusion
The overall LR-CCE SSI rate was 1.1%. SAP was associated with a 50% lower overall SSI rate.
Study context
- Population
- Adults undergoing low-risk cholecystectomy (elective endoscopic, age <70, no active cholecystitis, ASA score <3, operating time <120 minutes, no foreign material), 66 Swiss hospitals, 2009–2020
- Participants
- 12,521 adults · 66 Swiss hospitals
- Exposure
- Surgical antimicrobial prophylaxis vs no surgical antimicrobial prophylaxis (SAP)
- SAPn = 9,269
- Outcome
- Occurrence of SSI
- Follow-up
- Until day 30
Methodological detailsmulticentre, surveillance registry, adjusted logistic regression
- Multicentre
- Surveillance registry
- Adjusted logistic regression
Main finding
SSI
Adjusted odds ratio
0.50
95% CI 0.35–0.70
P < 0.001
SAP vs No SAP
aOR 0.50 (95% CI 0.35–0.70); P < 0.001
As reported in the abstract
- Overall SSI rate
- 143 (1.1%)
- NNT to prevent 1 SSI
- 100
Observational data: associations, not effects.
Original publication
Surgical Antimicrobial Prophylaxis in Low-risk Cholecystectomies is Associated With Fewer Surgical Site Infections: Nationwide Cohort Study in Switzerland. Ann Surg. Published 17 June 2024. doi:10.
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