Timing of Cefuroxime Surgical Antimicrobial Prophylaxis and Its Association With Surgical Site Infections
Authors' conclusion
In this cohort study, administration of cefuroxime SAP closer to the incision time was associated with significantly lower odds of SSI
Study context
- Population
- Adults undergoing 1 of 11 major surgical procedures with cefuroxime surgical antimicrobial prophylaxis (SAP), Swissnoso surgical site infections (SSI) surveillance, 158 Swiss hospitals, 2009–2020of 538,967 surveilled
- Participants
- 222,439 adults
- Exposure
- Cefuroxime SAP 0–30 or 31–60 vs 61–120 minutes before incision
- 61 to 120 minutesn = 27,207reference
- 31 to 60 minutesn = 118,004
- 0 to 30 minutesn = 77,228
- Outcome
- SSI (Centers for Disease Control and Prevention definitions)
Methodological detailsmulticentre, surveillance system data, mixed-effects logistic regression adjusted
- Multicentre
- Surveillance system data
- Mixed-effects logistic regression adjusted
Main finding
As reported in the abstract
Each group vs 61 to 120 minutesAdjusted odds ratio (95% CI)P value
0 to 30 minutes
0.85(0.78–0.93)
P < 0.00131 to 60 minutes
0.91(0.84–0.98)
P = 0.01- SSI overall
- 5355 patients (2.4%)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| SSI, 10 to 25 vs 30 to 55 minutes before incision (subgroup) | 0.89 (0.82–0.97) | P = 0.009 | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Timing of Cefuroxime Surgical Antimicrobial Prophylaxis and Its Association With Surgical Site Infections. JAMA Netw Open. Published 1 June 2023. doi:10.
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