Surgical wound infiltration with liposomal bupivacaine admixture as an adjunct to intrathecal morphine for post-caesarean analgesia: a randomised, double-blind controlled trial
Primary result · Cumulative opioid consumption (oral morphine milligram equivalents)Result — go to the resultHodges-Lehmann estimate −3.05 mg 95% CI −5.9 to −1.4Authors' conclusion
In women undergoing scheduled caesarean delivery, wound infiltration with a liposomal bupivacaine-bupivacaine hydrochloride admixture significantly reduced postoperative opioid consumption and improved pain scores. It may be an effective opioid-sparing adjunct to intrathecal morphine.
Study context
- Population
- Patients undergoing elective caesarean delivery with intrathecal morphine (100 μg)patients randomised
- Participants
- 188 patients
- Comparison
- Wound infiltration with liposomal bupivacaine plus bupivacaine hydrochloride vs saline placebo, as an adjunct to intrathecal morphine
- Primary endpoint
- Cumulative opioid consumption (oral morphine milligram equivalents)
- Follow-up
- 48 h
Methodological detailsplacebo-controlled
- Placebo-controlled
Primary result
As reported in the abstract
Hodges-Lehmann estimate
−3.05 mg
95% CI −5.9 to −1.4
P = 0.002
By group
TREATMENTvs PLACEBO
Hodges-Lehmann estimate −3.05 mg (95% CI −5.9 to −1.4); P = 0.002
Secondary outcomes
| Outcome | RR for opioid-free status (95% CI) | P value | |
|---|---|---|---|
| Opioid-free status · 48 hFavoured treatment | 9.0 (2.1–37.8) | P < 0.001 | |
| 0.050.21520RR for opioid-free status (log scale) |
24-h opioid consumption
- Favoured treatment, P < 0.001
Movement-evoked pain · 24 h
- Favoured treatment, P < 0.001
Movement-evoked pain · 48 h
- Favoured treatment, P < 0.001
Time to first analgesic request
- Favoured treatment, P < 0.001
Original publication
Surgical wound infiltration with liposomal bupivacaine admixture as an adjunct to intrathecal morphine for post-caesarean analgesia: a randomised, double-blind controlled trial. Int J Obstet Anesth. Published 2 November 2026. doi:10.
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