Pediatric anesthesia & critical care
Survival and neurobehavioral outcomes following out-of-hospital cardiac arrest in pediatric patients with pre-existing morbidity: An analysis of the THAPCA out-of-hospital arrest data
Authors' conclusion
There was no difference in survival to 28 days following OHCA in children with pre-existing comorbidity compared to previously healthy children. The group with pre-existing comorbidity was more reliant on technology following arrest and exhibited worse neurobehavioral outcomes.
Study context
- Population
- Children aged 48 hours to 18 years after out-of-hospital cardiac arrest (OHCA), 36 pediatric ICUs in the US and Canada, 2009–2012
- Participants
- 151 vs 142
- Comparison
- Pre-arrest comorbidities vs none
- Comorbiditiesn = 151
- No comorbiditiesn = 142reference
- Primary endpoint
- Survival
- Follow-up
- 28 days
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
28-day survival
- No significant difference in 28-day survival between groups
Further findings
Neurobehavioral function among survivors (Pediatric Overall Performance Category (POPC), Pediatric Cerebral Performance Category (PCPC), VABS-II) · 12 months
- Worse POPC with comorbidities
- P = 0.016
- Worse PCPC with comorbidities
- P = 0.044
- Worse VABS-II with comorbidities
- P = 0.020
Technology dependence among survivors
- More tracheostomy at hospital discharge with comorbidities
- P = 0.034
- More supplemental oxygen at 3 months with comorbidities
- P = 0.039
- More supplemental oxygen at 12 months with comorbidities
- P = 0.034
- More mechanical ventilation at 12 months with comorbidities
- P = 0.041
Original publication
Survival and neurobehavioral outcomes following out-of-hospital cardiac arrest in pediatric patients with pre-existing morbidity: An analysis of the THAPCA out-of-hospital arrest data. Resuscitation. Published 15 February 2024. doi:10.
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