Survival and neurological outcome after bystander versus lay responder defibrillation in out-of-hospital cardiac arrest: A sub-study of the BOX trial

Sarkisian, L; Isse, YA; Gerke, O; Obling, LER; Paulin Beske, R; Grand, J; Schmidt, H; Højgaard, HF; Meyer, MAS; Borregaard, B; Hassager, C; Kjaergaard, J; Møller, JE

doi:10.1016/j.resuscitation.2023.110059

Cardiac arrest & resuscitation

Survival and neurological outcome after bystander versus lay responder defibrillation in out-of-hospital cardiac arrest: A sub-study of the BOX trial

ResuscitationPublished 25 Nov 2023Secondary analysis of the BOX randomised trial

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Authors' conclusion

In patients with OHCA, 3-month survival with good neurological outcome was higher in bystander defibrillated patients compared with lay responder defibrillated patients.

Study context

Population: Out-of-hospital cardiac arrest (OHCA) patients from two Danish tertiary cardiac ICUs, March 2017 to December 2021; EMS-witnessed OHCAs excluded
Participants: 715 patients

Comparison: Bystander vs lay responder defibrillation
Lay respondern = 81reference
Bystandern = 69
EMSn = 565
Primary endpoint: Survival with good neurological performance (Cerebral Performance Category 1 or 2)
Follow-up: 3 months

Methodological detailssub-study, 2 Danish tertiary cardiac ICUs

Sub-study
2 Danish tertiary cardiac ICUs

Primary result

As reported in the abstract

Survival with good neurological outcome

Lay responder65%

Bystander81%

P = 0.03

Further findings

Lay responder arrived before EMS: 125 cases (16%)

Original publication

Survival and neurological outcome after bystander versus lay responder defibrillation in out-of-hospital cardiac arrest: A sub-study of the BOX trial. Resuscitation. Published 25 November 2023. doi:10.1016/j.resuscitation.2023.110059

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