Hemodynamics, fluids & transfusion
Systematic review and meta-analysis of the treatment of hypernatremia in adult hospitalized patients: impact on mortality, morbidity, and treatment-related side effects
Pooled result · Mortality, overallResult — go to the resultOdds ratio 0.68 95 % CI 0.38–1.24Authors' conclusion
Faster sodium correction appears safe and may benefit patients with severe admission-related hypernatremia, particularly within the first 24 h.
Study context
- Population
- Hospitalized adults with hypernatremia12 studies
- Comparison
- Faster vs slower sodium correction of hypernatremia
- Outcome
- Mortality
Methodological detailsrandom-effects meta-analysis, PRISMA, subgroup analyses, Ovid MEDLINE, Embase, CENTRAL searched from inception to August 2024; 4445 articles reviewed
- Random-effects meta-analysis
- PRISMA
- Subgroup analyses
- Ovid MEDLINE, Embase, CENTRAL searched from inception to August 2024; 4445 articles reviewed
Pooled result
Mortality, overall
Odds ratio
0.68
95 % CI 0.38–1.24
Faster correction vs Slower correction
OR 0.68 (95 % CI 0.38–1.24)
As reported in the abstract
Further pooled results
| Outcome | OR (95 % CI) | |
|---|---|---|
| Mortality, correction at hospital admission (subgroup)Faster correction vs Slower correction · I2 = 2 % | 0.48 (0.35–0.68) | |
| Mortality, fast correction within first 24 h of diagnosis (subgroup)Faster correction vs Slower correction · I2 = 65 % | 0.48 (0.31–0.73) | |
| Mortality, severe hypernatremia (subgroup)Faster correction vs Slower correction · I2 = 79 % | 0.55 (0.33–0.92) | |
| 0.20.5125Odds ratio (log scale) |
Hospital LOS
- No significant difference by correction rate
Safety
Major neurological complications
- None reported when correction rate < 1 mmol/L/h
- 0
- Analysed qualitatively
Original publication
Systematic review and meta-analysis of the treatment of hypernatremia in adult hospitalized patients: impact on mortality, morbidity, and treatment-related side effects. J Crit Care. Published 6 January 2025. doi:10.
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