Hemodynamics, fluids & transfusion
Hemodynamic effects of slower versus faster intravenous fluid bolus rates in critically ill patients: An observational study
Authors' conclusion
In critically ill patients, crystalloid infusion at both fast and slow rates did not lead to immediate or sustained differences in MAP. However, fast infusion may result in a greater increase in CO.
Study context
- Population
- Critically ill patients
- Participants
- 146 patients
- Exposure
- 500 mL crystalloid at slow vs fast rate
- Slow raten = 71reference
- Fast raten = 75
- Outcome
- Adjusted difference in MAP
- Follow-up
- 1 h after end of infusion
Main finding
As reported in the abstract
Adjusted difference in MAP, overall mean marginal effect between groups
No difference in overall mean marginal effect on mean arterial pressure (MAP) between the groups
1.9 mmHg
95 % CI: −1.5 to 5.3 mmHgp = 0.27
Observational data: associations, not effects.
Further findings
| Outcome | Overall mean marginal effect (L/min) (95% CI) | P value |
|---|---|---|
| CO (subgroup with CO monitoring)Increase in CO in the fast rate group | 1.78 (0.08–3.48) | P = 0.04 |
Immediate effect on MAP, overall marginal effect between groups · 90 min
- No difference in immediate effect on MAP between the groups
- 1.1 mmHg (95 % CI: −2.3 to 4.6 mmHg); p = 0.52
Original publication
Hemodynamic effects of slower versus faster intravenous fluid bolus rates in critically ill patients: An observational study. J Crit Care. Published 18 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →