Microcirculation properties of 20 % albumin in sepsis; a randomised controlled trial
Authors' conclusion
This study demonstrates that a 20 % albumin bolus significantly enhances microcirculation in fluid-responsive patients with septic shock.
Study context
- Population
- Fluid-responsive patients with sepsis/septic shock100 analysed
- Participants
- 103 patients
- Comparison
- 20 % albumin bolus vs crystalloid resuscitation
- Albuminn = 52
- Controln = 51reference
- Primary endpoint
- Microcirculation (Side stream Dark Field camera, AVA 4.3 software)
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Microvascular density and activity · 15 min and 60 min
- Albumin: significant improvements in microvascular density and activity at 15 and 60 min (worse microcirculation at baseline)
- p < 0.005
Further findings
Fluid balance, vasopressor days, ICU LOS, mortality
- No significant differences between groups
Original publication
Microcirculation properties of 20 % albumin in sepsis; a randomised controlled trial. J Crit Care. Published 27 February 2025. doi:10.
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