Mortality effect of albumin fluid resuscitation in adults with septic shock: a systematic review and dual frequentist–bayesian meta-analysis of randomised trials
Pooled resultResult — go to the resultRelative risk 0.90 95% CI 0.83–0.99Authors' conclusion
In adults with septic shock, albumin-based resuscitation strategies are associated with a statistically significant reduction in mortality at the longest available follow-up, with a directionally concordant Bayesian estimate.
Study context
- Population
- Adults with septic shock
- Participants
- 3,273 adults · 7 randomised clinical trials (RCTs)
- Comparison
- Albumin-based vs crystalloid-based fluid resuscitation
- Outcome
- All-cause mortality
- Follow-up
- Longest available (up to 90 days)
Methodological detailsdual frequentist-Bayesian, random-effects models, PRISMA, preregistered protocol, GRADE: low certainty, Only 3 trials primarily recruited septic shock patients; remaining data from subgroups or extracted strata
- Dual frequentist-Bayesian
- Random-effects models
- PRISMA
- Preregistered protocol
- GRADE: low certainty
- Only 3 trials primarily recruited septic shock patients; remaining data from subgroups or extracted strata
Pooled result
As reported in the abstract
Relative risk
0.90
95% CI 0.83–0.99
P = 0.02
Albumin vs Crystalloid
RR 0.90 (95% CI 0.83–0.99); P = 0.02
Further pooled results
Pre-specified subgroups by albumin formulation, dosing strategy, baseline serum albumin (subgroup)
- No evidence of effect modification
Original publication
Mortality effect of albumin fluid resuscitation in adults with septic shock: a systematic review and dual frequentist–bayesian meta-analysis of randomised trials. Crit Care. Published 6 July 2026. doi:10.
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