Mortality Effect of Peripheral Perfusion-Guided Resuscitation in Vasodilatory Shock: A Systematic Review and Dual Frequentist-Bayesian Meta-Analysis of Randomized Trials
Pooled result · 28-day mortalityResult — go to the resultRelative risk 0.87 95% CI 0.76–1.01Authors' conclusion
Among adults with septic shock, peripheral perfusion-guided resuscitation yielded a lower 28-day mortality estimate that did not meet statistical significance in the frequentist analysis.
Study context
- Population
- Adults with vasodilatory shock (all eligible trials: septic shock)
- Participants
- 2,408 adults · 7 randomized controlled trials (RCTs)
- Comparison
- Peripheral perfusion-guided resuscitation vs standard care or lactate-guided resuscitation
- Outcome
- Mortality
- Follow-up
- 28 days
Methodological detailsprespecified dual frequentist-Bayesian framework, random-effects model, Bayesian hierarchical model
- Prespecified dual frequentist-Bayesian framework
- Random-effects model
- Bayesian hierarchical model
Pooled result
28-day mortality
Relative risk
0.87
95% CI 0.76–1.01
P = 0.06
Peripheral perfusion-guided resuscitation vs Standard care or lactate-guided resuscitation
RR 0.87 (95% CI 0.76–1.01); P = 0.06
As reported in the abstract
- Bayesian posterior probability that RR is less than 1, broadly consistent across alternative priors
- 97.2%
Original publication
Mortality Effect of Peripheral Perfusion-Guided Resuscitation in Vasodilatory Shock: A Systematic Review and Dual Frequentist-Bayesian Meta-Analysis of Randomized Trials. Crit Care Med. Published 11 September 2026. doi:10.
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