Target attainment and population pharmacokinetics of flucloxacillin in critically ill patients: a multicenter study
Authors' conclusion
Based on our dosing simulations, standard flucloxacillin daily doses of up to 12 g may substantially enhance the risk of underdosing in critically ill patients.
Study context
- Population
- Adult critically ill patients given IV flucloxacillin, excluding RRT or liver cirrhosis, May 2017 to October 2019163 blood samples
- Participants
- 31 participants
- Exposure
- Simulated continuous infusion of flucloxacillin 12 g vs 24 g daily
- Outcome
- Target attainment: unbound serum concentration four times the minimum inhibitory concentration (MIC) for ≥ 50% of the dosing interval (ƒT>4xMIC ≥ 50%)
Methodological detailsmulticentre, Monte Carlo dosing simulations
- Multicentre
- Monte Carlo dosing simulations
Main finding
As reported in the abstract
Simulated target attainment (ƒT>2 mg/L ≥ 50%)
Observational data: associations, not effects.
Original publication
Target attainment and population pharmacokinetics of flucloxacillin in critically ill patients: a multicenter study. Crit Care. Published 3 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →