Perioperative medicine & outcomes
Targeted heart rate control using the funny current inhibitor ivabradine to reduce morbidity in patients undergoing noncardiac surgery: study protocol for a phase 2a, triple-blind, placebo-controlled randomised trial
Study context
- Population
- Patients aged ≥55 yr with cardiovascular risk factors for myocardial injury undergoing elective noncardiac surgeryplanned recruitment
- Participants
- 350 patients
- Planned comparison
- Ivabradine vs Placebo
- Primary endpoint
- Myocardial injury associated with morbidity (defined by Postoperative Morbidity Survey)
- Follow-up
- Within 7 days of randomisation
Methodological detailstriple-blind, international, multicentre, placebo-controlled, parallel group, 1:1 allocation using minimisation
- Triple-blind
- International
- Multicentre
- Placebo-controlled
- Parallel group
- 1:1 allocation using minimisation
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Targeted heart rate control using the funny current inhibitor ivabradine to reduce morbidity in patients undergoing noncardiac surgery: study protocol for a phase 2a, triple-blind, placebo-controlled randomised trial. BJA Open. Published 19 February 2025. doi:10.
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