Targeting capillary leak in experimental sepsis and endotoxemia: a systematic review of therapeutic agents, methods and models in animal studies
Authors' conclusion
Preclinical research on sepsis-induced capillary leak is characterized by methodological heterogeneity, a disproportionately high rate of studies reporting capillary leak reduction, and an overreliance on endotoxemia models.
Study context
- Population
- In vivo animal studies of experimental sepsis and endotoxemia evaluating interventions targeting capillary leak
- Participants
- 303 preclinical studies
- Outcome
- Characteristics of preclinical studies of interventions targeting capillary leak in experimental sepsis and endotoxemia (models, induction methods, capillary leak read-outs, targeted pathways, reported benefit)
Methodological detailsSYRCLE risk of bias assessment, translational quality score
- SYRCLE risk of bias assessment
- Translational quality score
Pooled result
As reported in the abstract
- Rodent models
- 81.2%
- Lipopolysaccharide-induced endotoxemia as induction method
- 59.7%
- Dye-based assays as capillary leak read-out in rodents
- 81.7%
- Targeted pathway: endothelial activation
- 12.2%
- Targeted pathway: intercellular junctions
- 11.2%
- Targeted pathway: nitric oxide pathway
- 8.9%
- Beneficial effect on ≥1 capillary leak outcome reported
- 93.1%
Original publication
Targeting capillary leak in experimental sepsis and endotoxemia: a systematic review of therapeutic agents, methods and models in animal studies. Crit Care. Published 14 August 2026. doi:10.
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