Temporal Trends in Mortality of Critically Ill Patients with Sepsis in the United Kingdom, 1988–2019
Authors' conclusion
Over a 30-year period, mortality for ICU admissions with sepsis decreased substantially. Although changes in case mix accounted for the majority of observed mortality reduction, there was an 8.8-percentage point reduction in mortality not explained by case mix.
Study context
- Population
- Patients admitted to 261 ICUs in the UK during 1988–1990 and 1996–2019 with nonsurgical sepsis
- Participants
- 426,812 patients · 261 ICUs
- Exposure
- ICU sepsis admissions in 2017-2019 vs 1988-1990
- Outcome
- Hospital mortality
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Each group vs 1988-1990Adjusted odds ratio (95% CI)
2017-2019
0.64(0.54–0.75)
- 2017-2019
- adjusted absolute reduction 8.8 % (95% CI 5.6–12.1)
- Observed reduction in hospital mortality (percentage points)
- 22.2
- Reduction explained by case mix changes (percentage points; 60% of total)
- 13.4
- Reduction not explained by measured factors (percentage points; 40% of total)
- 8.8
Observational data: associations, not effects.
Further findings
Case mix · value = median age
Median APACHE II acute physiology score 1988-1990 20 · 2017-2019 14
Genitourinary sepsis 1988-1990 2.0% · 2017-2019 13.4%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Temporal Trends in Mortality of Critically Ill Patients with Sepsis in the United Kingdom, 1988–2019. Am J Respir Crit Care Med. Published 1 March 2024. doi:10.
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