The Association Between Body Mass Index and Mortality Mediated by Medical and Mechanical Complications in Venovenous Extracorporeal Membrane Oxygenation
Authors' conclusion
We confirmed that patients with higher BMI requiring venovenous ECMO were less likely to die.
Study context
- Population
- Adults in the Extracorporeal Life Support Organization database who received venovenous extracorporeal membrane oxygenation (ECMO), January 1, 2015–December 31, 2021
- Participants
- 24,796 patient runs
- Exposure
- Body mass index (BMI) 20, 30 and 40 vs BMI 25 kg/m 2
- Outcome
- Hospital mortality
Methodological detailsinternational, multicentre registry, mediation analysis
- International
- Multicentre registry
- Mediation analysis
Main finding
As reported in the abstract
Each group vs BMI = 25Odds ratio (95% CI)
BMI = 2011% higher risk
1.11(1.08–1.15)
BMI = 308% lower risk
0.92(0.90–0.95)
BMI = 4018% lower risk
0.82(0.78–0.87)
- Deaths overall
- 10,361 (48%)
Observational data: associations, not effects.
Further findings
Complications
- BMI associated with mechanical, renal, pulmonary and neurologic complications
Mediation of BMI–mortality association
- Direct effect and mediation via pulmonary complications; mechanical, RRT and neurologic complications acted as suppressors
Original publication
The Association Between Body Mass Index and Mortality Mediated by Medical and Mechanical Complications in Venovenous Extracorporeal Membrane Oxygenation. Crit Care Med. Published 19 February 2025. doi:10.
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