Cardiothoracic & vascular anesthesia
The Association Between Preoperative Tamsulosin Use and Intraoperative Hypotension
Authors' conclusion
This study suggests that the use of tamsulosin prior to cardiac surgery is associated with an increased requirement for vasoactive support during CPB and upon ICU arrival.
Study context
- Population
- Male patients aged 40–90 years undergoing CABG or valve replacement surgery with cardiopulmonary bypass (CPB), April 1, 2021 to May 31, 2022
- Participants
- 159 male patients
- Exposure
- Tamsulosin vs No tamsulosin
- Tamsulosinn = 41
- No tamsulosinn = 118reference
- Outcome
- Vasopressor use in 30-minute time periods during CPB and upon ICU arrival
Methodological detailssingle-centre, tertiary referral hospital
- Single-centre
- Tertiary referral hospital
Main finding
As reported in the abstract
Vasopressor use (linear mixed-effects models)
- Unadjusted: tamsulosin users required significantly greater vasopressor support during all bypass time periods vs no tamsulosin
- all p ≤ 0.006
- Unadjusted: greater vasopressor support upon intensive care unit (ICU) arrival in tamsulosin users
- p = 0.014
- Adjusted for vasoplegia risk factors: tamsulosin group required significantly greater vasopressor support across all bypass time periods
- p < 0.001-0.033
Observational data: associations, not effects.
Original publication
The Association Between Preoperative Tamsulosin Use and Intraoperative Hypotension. J Cardiothorac Vasc Anesth. Published 23 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →