The association between the presence and burden of periodic discharges and outcome in septic patients: an observational prospective study
Main finding · Unfavourable functional outcome (UO)Result — go to the resultOdds ratio 3.82 95% CI 1.27–11.49Authors' conclusion
Our findings suggest that PDs and PDs burden are associated with SAE and might affect outcome in septic patients.
Study context
- Population
- Septic patients requiring ICU admission, without known chronic or acute intracranial disease or pre-existing acute encephalopathy, tertiary academic centre
- Participants
- 92 patients
- Exposure
- Periodic discharges (PDs) present vs absent
- Outcome
- Unfavourable functional outcome (UO, GOSE score < 5) and mortality
- Follow-up
- Hospital discharge
Methodological detailssingle-centre, continuous EEG monitoring, Continuous EEG started within 72 h after inclusion, up to 7 days, Consciousness and delirium assessed twice daily by a trained neuropsychologist
- Single-centre
- Continuous EEG monitoring
- Continuous EEG started within 72 h after inclusion, up to 7 days
- Consciousness and delirium assessed twice daily by a trained neuropsychologist
Main finding
Unfavourable functional outcome (UO)
Odds ratio
3.82
95% CI 1.27–11.49
P = 0.02
Events by group
PDs
41%
15 events
PDs vs No PDs
OR 3.82 (95% CI 1.27–11.49); P = 0.02
As reported in the abstract
- Patients with PDs
- Nearly 25%
- PDs presence associated with UO (univariate)
- P = 0.005
- PDs burden associated with UO (univariate)
- P = 0.008
- PDs burden vs GOSE, Spearman's ρ
- - 0.2
- Reactivity (majority of patients) associated with functional outcome and mortality
- P = 0.044
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| Sepsis-associated encephalopathy (SAE)Independent association | 8.98 (1.11–72.8) | P = 0.04 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
The association between the presence and burden of periodic discharges and outcome in septic patients: an observational prospective study. Crit Care. Published 9 May 2023. doi:10.
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