Pain medicine

The Association of Cannabis Use After Discharge From Surgery With Opioid Consumption and Patient-reported Outcomes

Ann SurgPublished Retrospective cohort study

Main finding · Postdischarge opioid consumption (opioid pills)Result — go to the resultAdditional opioid pills 1.0 opioid pills 95% CI 0.4–1.5

Authors' conclusion

Patient-reported cannabis use, to treat postoperative pain, was associated with increased opioid consumption after discharge from surgery that was of clinically insignificant amounts, but worse pain and other postoperative patient-reported outcomes.

Study context

Population
Patients undergoing 16 procedure types at 69 Michigan Surgical Quality Collaborative hospitals, January–October 2021
Participants
11,314 patients · 69 hospitals
Exposure
Cannabis use vs no cannabis use for pain after discharge from surgery
  • Cannabisn = 581
Outcome
Postdischarge opioid consumption
Methodological detailsmulticentre registry
  • Multicentre registry

Main finding

Postdischarge opioid consumption (opioid pills)

Additional opioid pills

1.0 opioid pills

95% CI 0.4–1.5

As reported in the abstract

Observational data: associations, not effects.

Further findings

OutcomeaOR (95% CI)
Moderate-to-severe surgical site pain · 1 week1.7 (1.4–2.1)
Moderate-to-severe surgical site pain · 1 month2.1 (1.7–2.7)

High satisfaction

P < 0.001

Best quality of life

P < 0.001

No regret to undergo surgery

P < 0.001

Original publication

The Association of Cannabis Use After Discharge From Surgery With Opioid Consumption and Patient-reported Outcomes. Ann Surg. Published 28 August 2023. doi:10.1097/sla.0000000000006085

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