Cardiac arrest & resuscitation
The association of non-prescription drug use preceding out-of-hospital cardiac arrest and clinical outcomes
Authors' conclusion
In unadjusted models, DA-OHCA was associated with an improved odds of survival and favourable neurological outcomes at hospital discharge, compared to other OHCA. However, we did not detect an association in adjusted analyses.
Study context
- Population
- EMS-treated Out-of-hospital Cardiac Arrest (OHCA) in the British Columbia Cardiac Arrest Registry, January/2019-June/2023
- Participants
- 18,426 participants
- Exposure
- Non-prescription drug-associated OHCA vs other OHCA
- DA-OHCAn = 2,171
- Outcome
- Favourable neurological outcome (CPC 1-2) and survival at hospital discharge, and return of spontaneous circulation (ROSC)
- Follow-up
- Hospital discharge
Methodological detailsregistry-based
- Registry-based
Main finding
As reported in the abstract
Favourable neurological outcome (CPC 1-2)
DA-OHCA vs Other OHCADifference (95% CI)
Unadjusted
1.8%(0.49–3.2)
DA-OHCA vs Other OHCAOdds ratio (95% CI)
Adjusted
1.08(0.87–1.33)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Survival to hospital dischargeAdjusted | 1.13 (0.93–1.38) | |
| ROSCAdjusted | 1.13 (1.004–1.27) | |
| 0.512Odds ratio (log scale) |
Original publication
The association of non-prescription drug use preceding out-of-hospital cardiac arrest and clinical outcomes. Resuscitation. Published 10 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →