Neuroanesthesia & neurocritical care
The Association of Physiological and Pharmacological Anesthetic Parameters With Motor-Evoked Potentials: A Multivariable Longitudinal Mixed Model Analysis
Authors' conclusion
MAP, BIS, heart rate, and temperature were significantly associated with mTc-MEP amplitude and/or AUC.
Study context
- Population
- Consecutive patients undergoing elective spinal surgery with mTc-MEP monitoring75 (69.4%) included
- Participants
- 108 patients
- Outcome
- Association of anesthetic and physiological parameters with mTc-MEP amplitude and AUC
Methodological detailsconsecutive patients, multivariable longitudinal mixed model analysis, forward selection
- Consecutive patients
- Multivariable longitudinal mixed model analysis
- Forward selection
Main finding
As reported in the abstract
mTc-MEP amplitude and AUC
- mTc-MEP amplitude increase per 10 mm Hg increase in mean arterial pressure (MAP)
- 6.6% (95% CI 2.7%-10.4%)
- mTc-MEP amplitude increase per unit increase in BIS
- 2.79% (CI 2.26%-3.32%)
- MAP and BIS associated with mTc-MEP amplitude
- P < .001
- mTc-MEP AUC increase per 10 mm Hg increase in MAP
- 7.5% (CI 3.3%-11.7%)
- mTc-MEP AUC increase per unit increase in BIS
- 2.98% (CI 2.41%-3.54%)
- mTc-MEP AUC increase per beat per minute increase in heart rate
- 0.68% (CI 0.13%-1.23%; P = .01)
- mTc-MEP AUC decrease per degree increase in temperature
- 21.4% (CI −38.11% to −3.98%; P = .02)
Observational data: associations, not effects.
Original publication
The Association of Physiological and Pharmacological Anesthetic Parameters With Motor-Evoked Potentials: A Multivariable Longitudinal Mixed Model Analysis. Anesth Analg. Published 28 December 2023. doi:10.
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